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目的：在动物体内验证多沙唑嗪临床毒副反应及性质。方法：以多沙唑嗪１，４，１６ｍｇ／ｋｇ，给犬连续９０ｄ，ｐｏ，并设对照组，观察用药期间毒性反应及停药２１ｄ期间恢复情况。结果：高剂量组在给药初期动物出现眼睑下垂、结膜及巩膜充血、瞬膜弛缓、眼分泌增多等现象，部分动物活动量减少，当继续用药１０～２０ｄ后症状逐渐减轻并消失。在用药６３ｄ后，动物体重增长明显减慢（Ｐ＜０．０５），且在６０ｄ及９０ｄＢＵＮ含量明显增高（Ｐ＜０．０５）。停药后均恢复正常。中、低剂量组未见异常现象。结论：多沙唑嗪对犬的无毒反应剂量大约为４ｍｇ／ｋｇ。
Objective: To verify the clinical side effects and the nature of doxazosin in animals. Methods: Doxazosin 1, 4, 16 mg / kg, continuous 90 d, po, and the control group, to observe the toxicity during the treatment and recovery during 21 d withdrawal. Results: In the high dose group, eyelid ptosis, conjunctival and scleral hyperemia, transient membrane relaxation and ocular excretion were observed in the high dose group. Some animals decreased their activity. After 10 to 20 days, the symptoms gradually disappeared and disappeared. After 63 days of treatment, the body weight gain of animals slowed down significantly (P <0.05), and the contents of 60d and 90dBUN increased significantly (P <0.05). After stopping all returned to normal. Medium and low dose group no abnormal phenomenon. Conclusion: Doxazosin non-toxic dose of dogs is about 4mg / kg.