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目的探讨短期胰岛素强化治疗对初诊2型糖尿病患者胰岛功能的影响。方法 70例初诊2型糖尿病患者,均接受短期胰岛素强化治疗,治疗前后行口服葡糖糖耐量试验(OGTT),比较治疗前后患者空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、空腹胰岛素浓度(FIns)、胰岛β-细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)及早时相胰岛素分泌指数(I30/G30)差异。结果治疗后患者FBG为(6.49±2.18)mmol/L、2 h PG为(7.62±1.58)mmol/L均明显低于治疗前的(13.54±2.58)、(17.56±4.62)mmol/L,比较差异均具有统计学意义(P<0.05);治疗后患者Hb A1c为(9.05±1.54)%,低于治疗前的(9.68±1.05)%,但比较差异无统计学意义(P>0.05)。治疗后患者FIns、HOMA-β及I30/G30均明显降低,而HOMA-IR较前明显升高,比较差异均有统计学意义(P<0.05)。结论短期胰岛素强化治疗能够明显降低初诊2型糖尿病患者血糖水平,改善胰岛功能并减轻胰岛素抵抗,值得在临床中推广应用。
Objective To investigate the effect of short-term intensive insulin therapy on islet function in newly diagnosed type 2 diabetic patients. Methods Seventy patients with newly diagnosed type 2 diabetes mellitus received short-term intensive insulin therapy. Oral glucose tolerance test (OGTT) was performed before and after treatment. Fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h PG) Hb A1c, FIns, HOMA-β, HOMA-IR and I30 / G30 were measured. Results After treatment, FBG was (6.49 ± 2.18) mmol / L in 2 h and (7.62 ± 1.58) mmol / L in 2 h were significantly lower than those before treatment (13.54 ± 2.58) and (17.56 ± 4.62) mmol / L, respectively (9.05 ± 1.54)%, which was lower than that before treatment (9.68 ± 1.05)%, but the difference was not statistically significant (P> 0.05). After treatment, the FIns, HOMA-β and I30 / G30 were significantly decreased, while the HOMA-IR was significantly increased compared with the previous, the difference was statistically significant (P <0.05). Conclusion Short-term intensive insulin therapy can significantly reduce the newly diagnosed type 2 diabetes patients with blood glucose levels, improve pancreatic islet function and reduce insulin resistance, it is worth in the clinical application.