论文部分内容阅读
目的 探讨乌司他丁对肝切除术后肝功能的保护作用。方法 将临床60例肝癌行肝叶切除术的病人随机分成两组,对照组25例,常规肝切除和护肝治疗;实验组35例,除同对照组治疗之外,术前1d到术后第7天静脉使用乌司他丁20万U。检测两组术前和术后第1、3、5、7天肝功能:胆红素(TB)、谷丙转氨酶(AST)、谷草转氨酶(ALT)。结果 实验组在术中第一肝门阻断10min以上组和右半肝切除病例中,术后AST、ALT以及TB比对照组明显降低,P<0.05,有统计学意义,并且术后1周内肝功能恢复正常。结论 乌司他丁对肝切除术后肝功能有保护作用。
Objective To investigate the protective effect of ulinastatin on liver function after liver resection. Methods Sixty patients with hepatocellular carcinoma who underwent hepatectomy were randomly divided into two groups, control group (n = 25), conventional hepatectomy and hepatoprotective therapy. In the experimental group, 35 cases except the control group, On the seventh day, 200,000 U of ulinastatin was intravenously administered. The liver function of the two groups were detected preoperatively and on the 1st, 3rd, 5th, 7th day after operation: bilirubin (TB), alanine aminotransferase (AST) and aspartate aminotransferase (ALT). Results In the cases of the first hepatic hilar block more than 10 minutes and right hemihepatectomy, the postoperative AST, ALT and TB in the experimental group were significantly lower than those in the control group (P <0.05), and the difference was statistically significant Liver function returned to normal. Conclusion Ulinastatin has a protective effect on liver function after liver resection.