论文部分内容阅读
能量代谢重编程是肿瘤的重要特征之一.快速增殖的肿瘤细胞以高速率的糖酵解为主要的供能方式,促进肿瘤对缺氧等应激环境的适应,增加肿瘤的恶性潜能.转录因子对糖代谢基因的调控是肿瘤能量代谢重编程的重要机制之一.低氧诱导因子1(hypoxia inducible factor-1,HIF-1),c-Myc,p53,NK-κB等作为调控糖代谢的主要转录因子影响糖酵解、三羧酸循环中相关基因的表达,同时糖代谢酶或产物也能反馈调节转录因子的活性.转录因子与糖代谢的相互作用关系为靶向代谢的抗癌药物的研究提供了新思路.
Energy metabolism reprogramming is one of the most important features of tumor.The rapid proliferation of tumor cells with high rates of glycolysis as the main energy supply, promote tumor adaptation to hypoxic conditions such as stress and increase the malignant potential of the tumor Transcription Regulation of glucose metabolism genes by genes is one of the important mechanisms of tumor energy metabolism reprogramming.Hypoxia inducible factor-1 (HIF-1), c-Myc, p53, NK-κB, Of the major transcription factors affect the glycolysis, tricarboxylic acid cycle related gene expression, while sugar metabolism enzymes or products can also feedback regulation of transcription factor activity.Transcription factor and glucose metabolism of the interaction between the targeted metabolism of anti-cancer Drug research provides a new idea.