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目的分析金纳多治疗急性脑梗死患者血浆白细胞介素6(IL-6)和C-反应蛋白(CRP)的变化,探讨金纳多在急性缺血性脑血管病治疗中的相关机制。方法选择44例发病<72h的脑梗死患者,予金纳多注射液10ml加入5%葡萄糖液250ml中静脉滴注,1次/d,14d为1个疗程;对照组41例发病<72h的脑梗死患者予低分子右旋糖酐500ml静脉滴注,1次/d,14d为1个疗程。对每个病例均作头部磁共振扫描。酶免法(ELLISA)测定上述因子,比较它们的差异。结果金纳多治疗组和脑梗死组7d,患者血浆IL-6和CRP比对照组明显降低。结论金纳多治疗急性脑梗死与其抗炎症反应有关。
Objective To analyze the changes of plasma interleukin 6 (IL-6) and C-reactive protein (CRP) in patients with acute cerebral infarction treated with Ginaton and explore the mechanism of Ginaton in the treatment of acute ischemic cerebrovascular disease. Methods Forty-four patients with cerebral infarction who had onset of <72 h were enrolled in this study. 10 ml of Ginaton injection and 250 ml of 5% dextrose solution were injected intravenously once a day for 14 days. In control group, 41 cases Patients with infarction to low molecular weight dextran 500ml intravenous infusion, 1 / d, 14d for a course of treatment. For each case for head MRI. Enzyme-linked immunosorbent assay (ELLISA) to determine the above factors, compare their differences. Results The levels of IL-6 and CRP in plasma of patients treated with Ginaton treatment and cerebral infarction group were significantly lower than those of control group. Conclusion Ginaton treatment of acute cerebral infarction and its anti-inflammatory response.