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Objective:To investigate the effect of sevoflurane on tissue permeability of lung ischemiareperfusion injury（LIRI）in rats.Methods:A total of 45 wistar rats were randomly divided into3 groupsⅠ,Ⅱ,Ⅲ.Modified Eppinger method was adopted to establish the rat lung ischemiareperfusion injury model.GroupⅠserved as the control group,groupⅡas ischemia reperfusion group,groupⅢas sevoflurane ischemia-reperfusion group.Blood gas index,lung permeability index（LPI）change,lung tissue pathology change and lung water content were observed and compared between groups of rats at different time points.Results:During ischemia reperfusion,all rats kept balance of the MAP during different time points,SPO2 of groupⅡandⅢdecreased significantly thanⅠgroup（P<0.05）;after reperfusion lung permeability index in GroupⅡandⅢwas higher than the control group significantly（P<0.05）,120 min after reperfusion LPI change and iujury of groupⅢwas significantly lower thanⅡgroup（P<0.05）;interstitial and alveolar cavity effusion in of groupⅢwere lower than that of groupⅡ.Conclusions:Sevoflurane pretreatment can reduce the lung tissue permeability,and LIRI plays a protective role in LIRI.