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作者从1968年～1977年用利福平治疗了100多例瘤型麻风患者,本文报道这方面的短期和长期的临床试验以及鼠足垫接种的细菌学研究的结果。细菌学研究:采用正常的CBA鼠和经过胸腺摘除和X线照射而致成免疫缺陷的CBA鼠(T/R),将麻风杆菌接种于后足垫。取10株麻风杆菌(4株取自未经治疗的患者,6株取自耐砜类药的瘤型麻风),接种分4组(每组6只正常鼠)。3组分别用含利福平浓度为0.01%,0.005%,0.0025%的饲料喂养,第4组不治疗,检测利福平的最低有效量。用取自治疗前和治疗期间患者的组织,制成菌悬液,接种于正常的或T/R鼠,以检测麻风杆菌的存活率。临床研究:包括下述试验。
The authors treated more than 100 patients with leprosy with rifampicin from 1968 to 1977. This article reports on the results of short-term and long-term clinical trials in this area and bacteriological studies of mouse footpad inoculations. Bacteriological studies: Leptospira was inoculated on the hind paw pads using normal CBA mice and CBA mice (T / R) that became immunodeficient after thymic excision and X-ray irradiation. Ten M. leprae strains (4 from untreated patients, 6 from leprosy-resistant leprosy) were inoculated into 4 groups (6 normal mice per group). The three groups were fed with feed containing rifampicin at concentrations of 0.01%, 0.005% and 0.0025%, respectively. The fourth group was not treated and the lowest effective dose of rifampicin was tested. Bacterial suspensions were prepared from the tissue of the patient prior to and during treatment and inoculated into normal or T / R mice to test the survival rate of Leprosy. Clinical research: Including the following test.