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目的制备地塞米松血管内支架的涂层,观察体外缓释特性。方法采用喷涂、浸涂两种方法制备支架,以高效液相色谱仪检测载药量,并进行体外药物缓释测定。结果喷涂支架的载药量为(24.26±5.23)μg,浸涂4d的载药量为(93.15±7.83)μg。浸涂4d的支架,药物缓慢释放,15d时释放84%。结论制备的支架具有明显的缓释作用。
Objective To prepare the coating of dexamethasone endovascular stent and observe the in vitro sustained release characteristics. Methods Sprayed and dip-coated two methods were used to prepare scaffolds. The drug loadings were detected by high performance liquid chromatography (HPLC) and drug release was measured in vitro. Results The drug-loading volume of spray-coated stent was (24.26 ± 5.23) μg, and that of dip-coated stent was (93.15 ± 7.83) μg for 4 days. 4d dip coating stent, slow release of drugs, 84d release 15d. Conclusion The scaffold prepared has obvious sustained release effect.