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目的:观察益气败毒汤对荷瘤小鼠血清TNF-α、IL-6含量的影响,初步探讨其抗肿瘤作用机理。方法:以移植性肉瘤S_(180)小鼠为研究对象,用双抗夹心ELISA法检测荷瘤小鼠血清TNF -α、IL-6含量。结果:益气败毒汤高、中、低剂量对S_(180)荷瘤小鼠的抑瘤率分别为15.07%、36.89%、31.49%,显著提高荷瘤小鼠血清TNF—α、IL-6含量。结论:益气败毒汤可能是通过提高荷瘤小鼠血清TNF-α、IL-6含量而发挥抑瘤作用。从而为其在临床上治疗肿瘤提供理论依据。
Objective: To observe the effect of Yiqibaidu Decoction on the content of serum TNF-α and IL-6 in tumor-bearing mice, and to explore its anti-tumor mechanism. Methods: The transplanted sarcoma S_(180) mice were used as the research object. The levels of serum TNF-α and IL-6 in tumor-bearing mice were detected by double antibody sandwich ELISA. Results: The tumor inhibition rates of high-, middle-, and low-dose Yiqibaidu Decoction on S 180 tumor-bearing mice were respectively 15.07%, 36.89%, and 31.49%, which significantly increased serum TNF-α and IL- in tumor-bearing mice. 6 content. Conclusion: Yiqibaidu Decoction may play a role in inhibiting tumor by increasing serum TNF-α and IL-6 levels in tumor-bearing mice. In order to provide a theoretical basis for clinical treatment of tumors.