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【目的】探讨热疗与化疗结合在卵巢恶性肿瘤治疗中的作用。【方法】采用热化疗治疗２２例术后有残余肿块的卵巢恶性肿瘤患者（实验组），与同期１２例常规化疗病人（对照组）进行比较。使用ＶＨＲ－９１５ＭＶ热疗机，手术中将带有导管的探头置于肿块下，当温度达到４１℃或较加温前上升３℃以上时继续保持４０ｍｉｎ。同时采用以顺铂为主的全身及腹腔双途径化疗，共计２～４疗程。【结果】２～３疗程后实验组完全缓解率（ＣＲ）４５．４％，部分缓解率（ＰＲ）２２．７％，有效率６８．１％。对照组ＣＲ率８３％，ＰＲ率２５％，有效率３３．３％，低于实验组。实验组有６例获得再次手术机会，其中２例术后病理证实达到临床及病理ＣＲ。该疗法无明显不良反应。【结论】热疗作一种辅助治疗与化疗有协同作用，可望提高晚期卵巢恶性肿瘤的治愈率，值得进一步研究
【Objective】 To explore the role of combination of hyperthermia and chemotherapy in the treatment of ovarian cancer. 【Methods】 Twenty-two patients with ovarian cancer with residual mass after operation (experimental group) were treated with thermochemotherapy and 12 patients with conventional chemotherapy (control group) during the same period. Using the VHR-915MV hyperthermia machine, the probe with the catheter was placed under the lump during the operation, and kept for 40 minutes when the temperature reached 41 ° C or more than 3 ° C before warming. At the same time using cisplatin-based systemic and peritoneal dual-path chemotherapy, a total of 2 to 4 courses. 【Results】 The complete remission rate (CR) 45.4%, partial remission rate (PR) 22.7% and effective rate 68.1% after 2 ~ 3 courses of treatment. The control group CR rate was 8.3%, PR rate 25%, effective rate 33.3%, lower than the experimental group. In the experimental group, 6 patients got the chance of reoperation, and 2 of them were pathologically confirmed clinically and pathologically. The treatment no obvious adverse reactions. 【Conclusion】 Hyperthermia as a adjuvant therapy has synergistic effect with chemotherapy, which is expected to improve the cure rate of advanced ovarian cancer and deserves further study