The non-steroidal selective estrogen receptor modulator (SERM) tamoxifen (tam) is widely used in the treatment of breast cancer.SERMs are competitive inhibi
The mammalian target of rapamycin (mTOR) is a major component of the PI3K/AKT signaling pathway that is dysregulated in 50% of all human malignancies.Rapamy
The breast cancer tumor suppressor, BRCA1, is mutated in many familial breast cancers and functions in the cell nucleus and at the centrosome to regulate DN