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目的分析安徽省2010~2011年疑似预防接种异常反应(AEFI)的发生特征,评价预防接种的安全性。方法采用描述性流行病学方法对2010~2011年安徽省疑似预防接种异常反应监测资料进行分析。结果安徽省2010~2011年共报告AEFI2 608例,报告的AEFI中≤1岁组最多、1 047例、占40.15%,男女性别比为1.5:1,AEFI报告主要集中在6~9月份,即2010年麻疹强化和2011年流脑疫苗观察性研究期间,接种疫苗以后时间间隔为1天内发生的AEFI最多、为2 268例、占86.96%,2010年报告一般反应567例、异常反应53例、接种事故1例、偶合症34例,2011年报告一般反应1 847例、异常反应93例、偶合症12例、心因性反应1例;两年AEFI疫苗分布中最多的百白破(无细胞)疫苗占27.73%、报告发生率1.84/10万剂,安徽省48h内发生率和调查率分别是94.51%和98.4%。结论 AEFI常发生在1岁以内的儿童,强化免疫或群体性接种时期、接种后1d内发生AEFI最多。预防接种异常反应报告发生率均在预期发生范围内。
Objective To analyze the occurrence characteristics of suspected immunization anaphylaxis (AEFI) in Anhui Province from 2010 to 2011 and evaluate the safety of vaccination. Methods Descriptive epidemiological methods were used to analyze the surveillance data of suspected immunization anomalies from 2010 to 2011 in Anhui province. Results A total of 608 AEFI2 cases were reported in Anhui province during 2010-2011. The reported AEFI ≤ 1 year old group was the most, 1 047 cases (40.15%), the male-to-female sex ratio was 1.5: 1. The AEFI report mainly focused on June to September, During the 2010 measles intensification and observational study of meningococcal vaccine in 2011, the most frequent AEFI occurred within 1 day after vaccination was 2 268 cases (86.96%). In 2010, there were 567 cases of general reaction and 53 cases of abnormal reaction. Inoculation accident in 1 case, 34 cases of coupling, reported in 2011 the general reaction of 1 847 cases, 93 cases of abnormal reaction, 12 cases of coupling, 1 case of cardiogenic response; two years of AEFI vaccine distribution of the most Baibule broken (cell-free ) Vaccines accounted for 27.73%, the reporting rate of 1.84 / 10 million doses, the incidence and survey rate within 48h in Anhui Province were 94.51% and 98.4%. Conclusions AEFI often occurs in children under 1 year of age with intensive immunization or group vaccination, and most AEFI occurs within 1 day after inoculation. The incidence of abnormal vaccination reports were within the expected range.