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目的:观察中西医结合治疗原发性高血压肾损害的临床疗效。方法:将100例原发性高血压肾损害患者随机分为治疗组和对照组,对照组50例采用常规西药降压治疗,治疗组50例在常规西医治疗的基础上加用补肾活血中药治疗。两组疗程均为3个月。观察两组治疗前后血压、夜尿次数、血肌酐(Scr)、内生肌酐清除率(Ccr)及24h尿蛋白定量、血β2微球蛋白(β2-Mg)变化。结果:两组治疗后血压均较治疗前显著降低(P<0.01),但组间比较无统计学意义(P>0.05);夜尿次数比较:治疗组治疗后夜尿次数较治疗前显著减少(P<0.01),与对照组治疗后比较有显著差异(P<0.01);肾功能比较:两组Scr水平治疗后差异无统计学意义(P>0.05),治疗组治疗后Ccr较治疗前显著提高(P<0.01),与对照组治疗后比较差异有显著性,对照组治疗前后差异无显著性(P>0.05);24h尿蛋白和血β2-Mg比较:对照组上述指标比较无统计学意义(P>0.05),治疗组治疗后上述指标较治疗前明显降低(P<0.01),与对照组治疗后比较差异有显著性(P<0.01)。结论:中西医结合治疗原发性高血压肾损害能减少夜尿次数,减轻肾损害,延缓肾功能恶化,从而保护肾脏。
Objective: To observe the clinical efficacy of integrated traditional Chinese and western medicine in treating primary hypertensive renal damage. Methods: One hundred patients with essential hypertension with renal impairment were randomly divided into treatment group and control group. Fifty patients in control group were treated with conventional antihypertensive drugs. Fifty patients in treatment group were treated with traditional Chinese medicine plus Bushen Huoxue Chinese medicine . Two groups of treatment are 3 months. The changes of blood pressure, urinary nocturnal frequency, Scr, Ccr, 24h urinary protein and β2-microglobulin in blood were observed before and after treatment. Results: The blood pressure of the two groups after treatment was significantly lower than that before treatment (P <0.01), but there was no significant difference between the two groups (P> 0.05). The frequency of nocturnal urination was significantly decreased (P <0.01), compared with the control group after treatment was significantly different (P <0.01); renal function comparison: the two groups Scr level after treatment was no significant difference (P> 0.05), Ccr after treatment in the treatment group than before treatment (P <0.01), but there was no significant difference between the two groups (P> 0.05). There was no significant difference between the two groups before and after treatment (P> 0.05). After treatment, the above indexes in the treatment group were significantly lower than those before treatment (P <0.01), and were significantly different from those in the control group after treatment (P <0.01). Conclusion: Integrative Medicine for the treatment of primary hypertensive renal damage can reduce the number of nocturia, reduce renal damage, delay the deterioration of renal function, thus protecting the kidneys.