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肠道病毒是新生儿感染的常见病因。在夏、秋肠道病毒流行季节,≤1月龄婴儿的发病率为13%,有21%的新生儿出现临床症状。新生儿肠道病毒感染可能是严重的,尤其是在新生2周期间,脓毒病、脑膜脑炎、心肌炎和(或)肝炎有显著的发病率和(或)病死率。尚无特异性抗病毒治疗法。免疫球蛋白曾依据经验用于阻断托儿所肠道病毒的暴发流行,并治疗少数发病的新生儿,但效果未能肯定。本文作者对16例有肠道病毒感染症状的新生儿及其母亲进行病毒学和血清学应答研究,包括静脉注射免疫球蛋白(IVIG)治疗的效果进行了前瞻性研究,结果如下。
Enterovirus is a common cause of neonatal infection. In the summer and autumn, the incidence of enteric infections in infants less than 1 month old was 13% in the season of intestinal gut virus, and 21% of newborns developed clinical symptoms. Neonatal enterovirus infection can be severe, especially with significant morbidity and / or mortality in sepsis, meningoencephalitis, myocarditis and / or hepatitis during the first 2 weeks of life. There is no specific antiviral therapy. Immunoglobulins have been used empirically to block outbreaks of enterovirus infections in nurseries and to treat a small number of newborn infants, but the results have not been confirmed. The authors undertook a prospective study of the virological and serological response of 16 neonates with their symptoms of enterovirus infection and their mothers, including intravenous immunoglobulin (IVIG), the results of which are as follows.