目的:比较不同促排卵方案在体外受精-胚胎移植中应用的有效性,为促排卵方案临床合理应用提供依据。方法:2013年1月至2015年6月在我院生殖医学中心接受长方案(599个周期)、短方案(202个周期)及拮抗剂方案(123个周期)治疗的患者,观察其胚胎发育、临床妊娠结局及并发症情况等。结果:长方案组与拮抗剂组的平均年龄[(32.75±4.45)和(33.97±5.09)岁]及基础FSH[(7.23±2.32)和(7.97±3.57)IU/L]均显著低于短方案组[(36.04±4.87)岁;(10.07±5.37)IU/L]。长方案组的平均获卵数最高(13.27±6.69),短方案组最低(7.72±5.23),各组间差异显著。3组的平均促性腺激素释放激素激动剂(GnRH-a)用量无显著差异[(2 587±919)和(2 652±1 131),(2 498±1 111)IU],但短方案组和拮抗剂组的平均Gn天数[(10.01±2.19)和(9.88±2.06)d]及卵巢过度刺激综合征(OHSS)发生率(1.49%,0)均显著低于长方案组[(10.79±1.62)d;6.68%]。胚胎发育方面,3组的受精率、卵裂率、两原核(2PN)受精率、2PN卵裂率和异常受精率均无显著差异。长方案组和拮抗剂组的可利用胚胎率(47.56%和48.75%)显著低于短方案组(56.77%)。妊娠结局方面,3组方案的临床妊娠率(44.03%,42.86%,39.29%)、生化妊娠率(12.50%,11.43%,3.57%)和胚胎种植率(28.46%,27.66%,25.81%)均无统计学差异(P>0.05)。结论:长方案、短方案和拮抗剂方案具有相似的妊娠结局,但后两者的OHSS发生率显著低于长方案。 Objective: To compare the effectiveness of different ovulation induction programs in in vitro fertilization and embryo transfer, and provide evidence for the clinical application of ovulation induction. METHODS: From January 2013 to June 2015, patients with long-term (599 cycles), short-term (202 cycles) and antagonist (123 cycles) cycles of treatment at the Reproductive Medicine Center of our hospital were enrolled and their embryonic development , Clinical pregnancy outcomes and complications. RESULTS: The average age of the patients in the long-term and placebo groups (32.75 ± 4.45 vs 33.97 ± 5.09 years) and the basal FSH (7.23 ± 2.32 and 7.97 ± 3.57 IU / L) The program group [(36.04 ± 4.87) years; (10.07 ± 5.37) IU / L]. The average number of oocytes retrieved in the long-term regimen group was the highest (13.27 ± 6.69) and the shortest regimen group (7.72 ± 5.23), with significant differences among the groups. There were no significant differences in the mean GnRH-a levels in the 3 groups ([2 587 ± 9 19] and (2 652 ± 1 131), (2 498 ± 1 1 1 1 1) IU] (10.01 ± 2.19) and (9.88 ± 2.06) d] and the incidence of ovarian hyperstimulation syndrome (OHSS) (1.49%, 0) were significantly lower than those in the long-term treatment group [(10.79 ± 1.62) d; 6.68%]. There were no significant differences in fertilization rate, cleavage rate, 2PN fertilization rate, 2PN cleavage rate and abnormal fertilization rate among the three groups in terms of embryo development. The available embryos rates (47.56% and 48.75%) in the long and antagonist groups were significantly lower than those in the short-term group (56.77%). In terms of pregnancy outcome, the clinical pregnancy rates (44.03%, 42.86%, 39.29%), biochemical pregnancy rates (12.50%, 11.43%, 3.57%) and embryo implantation rates (28.46%, 27.66%, 25.81% No statistical difference (P> 0.05). CONCLUSIONS: Long-term, short-course and antagonist regimens have similar pregnancy outcomes, but the incidence of OHSS in the latter two groups is significantly lower than in the long-term regimen.