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作者对Knapp等[见本刊11(5):257,1984]认为甲腈咪胍与利多卡因有相互作用的结论提出质疑:①甲腈咪胍首剂是静脉给药,以后每6小时口服1次共3次。甲腈咪胍口服与静脉给药的生物利用度不同,难以阐明甲腈咪胍对利多卡因的药物代谢动力学有影响。②Knapp等述说利多卡因以2～3mg/kg体重/min滴注长达26小时。可能印刷错误,应为2～3mg/min,因为一般体重平均70kg的成人的剂量为20～50μg/kg体重/min。如果滴注利多卡因剂量不是按体重计算的话,在中毒组中血清利多卡因浓度较高只能反映用药剂量不恰当。③利多卡因滴注超过24小时,清除半寿期延长。如果利多卡因剂量对本身体重来说已过大的话,经26小时滴注血清利多卡因浓度仍较高可能是滴注剂量不恰当或清除半寿期延长。④Routledge等曾观察到急性心肌梗塞后头几
The authors of the Knapp et al [see 11 (5): 257, 1984] that the conclusions of the interaction between cimetidine and lidocaine questioned: ① acetonide first dose is administered intravenously every 6 hours Oral 1 times a total of 3 times. There is a difference in the bioavailability of citalidine between oral and intravenous administration, making it difficult to elucidate the effect of cetmizidine on the pharmacokinetics of lidocaine. ② Knapp said that lidocaine infusion of 2 ~ 3mg / kg body weight / min up to 26 hours. Probably the printing error should be 2 ~ 3mg / min, because the average body weight of 70kg adult dosage is 20 ~ 50μg / kg body weight / min. If the lidocaine instillation dose is not based on body weight, high concentration of lidocaine in the poisoning group only reflects the dose is not appropriate. ③ lidocaine infusion more than 24 hours, clear half-life extension. If the lidocaine dose is already too high for its own body weight, high concentrations of lidocaine over a 26-hour instillation may be due to an inadequate instillation dose or an extended clearance half-life. Routledge had observed the first few after acute myocardial infarction