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目的通过对急性脑血管病患者血糖(Glu)和糖化血清蛋白(GSP)水平联合检测,探讨其临床应用价值。方法对62例急性脑血管病患者及40例正常对照组的Glu和GSP分别采用葡萄糖氧化酶法和硝基四氮唑蓝(NBT)还原法进行检测。结果糖尿病继发急性脑血管病组和单纯急性脑血管病组的血糖水平均显著高于正常对照组(P<0.01);糖尿病继发急性脑血管病组的GSP水平显著高于单纯急性脑血管病组和正常对照组(P<0.01);单纯急性脑血管病组的GSP水平与对照组相比差异无统计学意义(P>0.05)。糖尿病继发急性脑血管病组Glu和GSP入院时与痊愈出院时比较差异无统计学意义(P>0.05);单纯急性脑血管病组患者入院时血糖水平显著高于痊愈出院时(P<0.01),但GSP水平差异无统计学意义(P>0.05)。结论联合检测Glu和GSP水平对鉴别急性脑血管病患者血糖的增高是应激性还是糖尿病性有着重要的临床意义。
Objective To investigate the clinical value of combined detection of Glu and Glycoprotein (GSP) levels in patients with acute cerebrovascular disease. Methods Glu and GSP in 62 patients with acute cerebrovascular disease and 40 normal controls were detected by glucose oxidase and nitroblue tetrazolium blue (NBT) respectively. Results The blood glucose levels of diabetic patients with acute cerebrovascular disease and patients with acute cerebrovascular disease were significantly higher than those of normal controls (P <0.01). The levels of GSP in diabetic patients with acute cerebrovascular disease were significantly higher than those in patients with acute cerebrovascular (P <0.01). The level of GSP in patients with acute cerebrovascular disease was not significantly different from that in the control group (P> 0.05). Glu and GSP secondary to diabetes mellitus were not significantly different between admission and recovery (P> 0.05); patients with acute cerebrovascular disease had significantly higher blood glucose levels at hospital admission (P <0.01) ), But there was no significant difference in GSP level (P> 0.05). Conclusions The combined detection of Glu and GSP levels has important clinical significance in discriminating whether the increase of blood glucose in patients with acute cerebrovascular disease is stress or diabetes.