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目的探讨L-选择素配体合成酶N-乙酰氨基葡萄糖-6-磺基转移酶在卵巢癌组织中的表达。方法选取卵巢癌患者28例(恶性组)、卵巢上皮性囊腺瘤患者10例(良性组)和围绝经期子宫肌瘤行全子宫及附件切除术患者所切除卵巢组织10例(对照组)。应用RT-PCR方法检测N-乙酰氨基葡萄糖-6-磺基转移酶在卵巢组织中的表达。结果恶性组N-乙酰氨基葡萄糖-6-磺基转移酶mRNA的表达水平显著高于良性组和对照组(P<0.05)。良性组和对照组的表达无差异。上皮性卵巢癌组织中N-乙酰氨基葡萄糖-6-磺基转移酶的mRNA的表达水平随临床分期增加而增加。结论N-乙酰氨基葡萄糖-6-磺基转移酶作为L-选择素配体合成酶在卵巢癌的发生、发展、转移侵袭过程中发挥作用。
Objective To investigate the expression of L-selectin ligand synthetase N-acetylglucosamine-6-sulfotransferase in ovarian cancer. Methods Totally 10 cases of ovariectomized patients (control group) were selected from 28 cases of ovarian cancer (malignant group), 10 cases of ovarian epithelial cystadenoma (benign group) and perimenopausal uterine fibroids . The expression of N-acetylglucosamine-6-sulfotransferase in ovarian tissue was detected by RT-PCR. Results The expression of N-acetylglucosamine-6-sulfotransferase mRNA in malignant group was significantly higher than that in benign group and control group (P <0.05). There was no difference between benign group and control group. The expression level of N-acetylglucosamine-6-sulfotransferase mRNA in epithelial ovarian cancer tissues increased with clinical stage. Conclusion N-acetylglucosamine-6-sulfotransferase plays an important role in the genesis, development, metastasis and invasion of ovarian cancer as L-selectin ligand synthase.