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采用成年Wistar大鼠为实验动物,雌雄各半。1组为基础饲料对照组,2组为高脂饲料对照组,3、4、5组分别以维生素E30、60、120mg/d灌胃,同时喂饲高脂饲料。实验8周后停止灌胃并改饲基础饲料5周至实验结束。 研究表明:1.高水平维生素E(60和120mg/d)对高脂饲料诱导的大鼠肝实质细胞中性脂肪蓄积及肝脏(体内)脂质过氧化的增加均有明显抑制作用。2.高水平维生素E(30、60和120mg/d)无明显降低大鼠血清胆固醇、甘油三酯及增加血清高密度脂蛋白胆固醇的作用。大鼠血清维生素E与胆固醇水平呈正相关关系,与高密度脂蛋白胆固醇无明显相关。提示维生素E可能并无抑制高脂血症的作用。3.喂饲高脂饲料时雌鼠血清胆固醇的反应比雄鼠敏感,维生素E灌胃时雌鼠血清维生素E的反应比雄鼠敏感,提示存在性别差异。
Adult Wistar rats as experimental animals, male and female. Group 1 as the basic feed control group, two groups of high-fat feed control group, 3,4,5 group were vitamin E30, 60,120mg / d gavage, while feeding high-fat diet. After 8 weeks of experiment, the gavage was stopped and the basal diet was changed for 5 weeks until the end of the experiment. The results showed that: (1) High levels of vitamin E (60 and 120 mg / d) significantly inhibited the accumulation of neutral fat and hepatic (in vivo) lipid peroxidation induced by high fat diet in rat hepatic parenchyma cells. High-level vitamin E (30, 60 and 120mg / d) did not significantly reduce the serum cholesterol, triglycerides and increase the role of serum high-density lipoprotein cholesterol. There was a positive correlation between serum vitamin E and cholesterol level in rats and no significant correlation with high density lipoprotein cholesterol. Tip Vitamin E may not inhibit the role of hyperlipidemia. 3. Feeding high-fat diet when female serum cholesterol response than male rats, vitamin E orally feeding rats serum vitamin E response than male mice, suggesting that there is gender differences.