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氧氟沙星系喹诺酮类衍生物之一。国内首次应用于治疗110例细菌性感染患者,其中呼吸系感染63例、单纯性及复杂性尿路感染分别为23及24例。剂量为100mg,每日1-3次,疗程3-22d。1 0例中分离到病原菌114株,98株为革兰阴性菌。治疗后临床有效率为86.4％,病原菌清除率为86.8％,不良反应发生率7.7％,表现为皮疹,心悸,失眠。本品抗菌谱广,抗菌活性强,口服吸收完全,有肯定的疗效及耐受性强。适用于各种细菌性感染,不宜用于孕妇及小儿。
Ofloxacin quinolone derivatives. For the first time in China for the treatment of 110 cases of bacterial infections in patients with respiratory infections in 63 cases, simple and complex urinary tract infections were 23 and 24 cases. The dose of 100mg, 1-3 times daily, course of treatment 3-22d. 114 isolates of pathogens were isolated from 10 cases, and 98 isolates were gram-negative bacteria. After treatment, the clinical effective rate was 86.4%, pathogenic bacteria clearance rate was 86.8%, adverse reaction rate was 7.7%, manifested as rash, palpitations, insomnia. This product broad antibacterial spectrum, strong antibacterial activity, oral absorption completely, there is a positive effect and tolerance. For a variety of bacterial infections, should not be used for pregnant women and children.