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目的:测定鸦胆子油的油水分配系数,并考察鸦胆子油乳在大鼠的肠吸收性质及机制。方法:采用经典摇瓶法测定鸦胆子油的油水分配系数(P);采用在体单向肠灌流法模型研究不同浓度鸦胆子油乳在大鼠的十二指肠、空肠、回肠及结肠的吸收情况,并测定其吸收速率常数(Ka)、吸收率(Fa)和表观渗透系数(Papp)。结果:鸦胆子油疏水常数logP的平均值为1.193。鸦胆子油乳在小肠(十二指肠、空肠、回肠)吸收较好,在结肠吸收较少且不规则。其Ka、Fa和Papp按十二指肠、空肠、回肠依次下降且差异显著(P<0.05),不同浓度在同一肠段随着浓度增加,吸收也随之增加,高浓度与低浓度相比,Fa和Papp差异显著(P<0.05),Ka没有显著性差异。结论:鸦胆子油透过生物膜的能力较强。鸦胆子油乳在十二指肠吸收最佳,在小肠内的吸收为一级动力学过程,并无自身浓度抑制作用,可能主要为被动转运机制。
Objective: To determine the oil-water partition coefficient of Brucea javanica oil and to study the intestinal absorption properties and mechanism of Brucea javanica oil emulsion in rats. Methods: The oil-water partition coefficient (J) of Brucea javanica oil was determined by classical shake-flask method. The rat model of duodenum, jejunum, ileum and colon Absorption and the absorption rate constant (Ka), absorption rate (Fa) and apparent permeability coefficient (Papp) were measured. Results: Brucea javanica oil hydrophobic constant logP average of 1.193. Brucea javanica oil in the small intestine (duodenum, jejunum, ileum) absorption better, less and irregular absorption in the colon. The Ka, Fa and Papp descending in the duodenum, jejunum and ileum were significantly different (P <0.05). The concentrations of different concentrations in the same intestine increased with the increase of absorption. The concentrations of high, , Fa and Papp significant difference (P <0.05), Ka no significant difference. Conclusion: Brucea javanica oil is more capable of penetrating biofilms. Brucea javanica oil emulsion in the duodenum best absorption in the small intestine absorption as a first-order kinetic process, there is no concentration inhibition, may be mainly passive transport mechanism.