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用葡聚糖—活性炭单点饱和分析法测定261例正常卵巢组织,148例卵巢恶性肿瘤组织胞浆雌激素受体和孕激素受体(ER.PR)。结果表明,正常卵巢组织ER和PR均值和阳性率均高于恶性卵巢肿瘤组织。卵巢恶性病变中,性腺间质类ER和PR含量均高于上皮性肿瘤.生殖细胞源性肿瘤和转移性癌。上皮性恶性肿瘤中,内膜样癌的ER和PR含量高于浆液性,粘液性及透明细胞癌。提示受体含量高者有用内分泌治疗的可能和推测有转好的预后。卵巢恶性肿瘤患者临床分期及月经状况与其ER阳性率有关,而与PR阳性率无关。
261 cases of normal ovarian tissue and 148 cases of ovarian cancer tissue cytoplasmic estrogen receptor and progesterone receptor (ER.PR) were measured by dextran - activated carbon single point saturation analysis. The results showed that the average and positive rates of ER and PR in normal ovarian tissue were higher than those in malignant ovarian tumor. Ovarian malignant lesions, gonadal stromal ER and PR levels were higher than epithelial tumors. Germ cell-derived tumors and metastatic carcinoma. Epithelial malignancies, endometrioid carcinoma of the ER and PR levels higher than serous, mucinous and clear cell carcinoma. Prompt recipients of high levels of endocrine therapy may be useful and speculated that a better prognosis. The clinical stage and menstrual status of patients with ovarian cancer were related to the positive rate of ER, but not to the positive rate of PR.