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氨茶碱作为支气管解痉剂已经沿用50多年了,到目前为止仍是临床应用最广泛的有效平喘药物之一。其结构是由2个分子的茶碱和一个分子的乙二胺形成的分子络合物,溶于水后呈强碱性(pH9.2～9.6)。进入人体后90％的氨茶碱在肝脏中进行生物转化,其代谢产物及10％的原药由肾脏排出体外。由于上述原因,在使用氨茶碱时应注意药物之间的相互作用。一、协同作用 1.与盐酸羟嗪(安他乐)合用安他乐有安定及抗组织胺作用,与氨茶碱合用止喘效果增强,而不良反应都相应降低,且疗效维持时间延长。氨茶碱与异丙嗪合用亦可收到相似的效果。
As a bronchial spasmolytic agent, aminophylline has been used for more than 50 years, and is still one of the most widely used effective antiasthmatic drugs in clinical practice so far. Its structure is composed of two molecules of theophylline and a molecule of ethylenediamine molecular complex, dissolved in water was strongly alkaline (pH 9.2 ~ 9.6). After entering the body 90% of aminophylline in the liver for bioconversion, the metabolites and 10% of the original drug excreted by the kidneys. Due to the above reasons, the use of aminophylline should pay attention to the interaction between drugs. First, the synergies 1. And hydrochloride hydroxylamine (and other music) Andritalol has stability and antihistamine effect, combined with aminophylline antiasthmatic effect increased, and the corresponding adverse reactions are reduced, and the efficacy of maintaining time. Aminophylline and promethazine combined also received similar results.