【摘 要】
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Objectives To elucidate the potential role of cytokines in the pathogenesis of coronary heart disease (CHD). Methods TNF-α and IFN-γ activity , IL-8 levels of
【机 构】
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Department of Cardiology, First Hospital of Xi’an JiaoTong University“,”Xi’an 710061 ,P R China“,”De
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Objectives To elucidate the potential role of cytokines in the pathogenesis of coronary heart disease (CHD). Methods TNF-α and IFN-γ activity , IL-8 levels of plasma and supeatants were measured in 62 patients with CHD and 30 health controls by methods of direct cytotoxicity assay, cytopathic effect inhibition test and ELISA respectively.Results Both TNF-α activity and IL-8 levels of plasma in CHD patients were higher and IFN-γ activity of supeatants in CHD patients were lower than those of healthy controls ( P ＜ 0. 001 ) , There have significant differences between healthy controls and the subgroups of CHD ( P ＜ 0.01 ). IL-8 levels of plasma increased with the advancing of the disease and there have obvious differences among subgroups of the illness ( P ＜ 0.05 ).TNF-α activity of plasma in stable angina pectoris ( SAP ) subgroup was lower than those of unstable angina pectoris ( UAP )and acute myocardial infarction (AMI) subgroups, the differences between SAP and UAP or AMI were significant ( P ＜ 0.05 ), But there have no significant differences between UAP and AMI ( P ＞ 0.05 ). However, IFN-γ activity of supeatants showed no difference among any subgroups. Conclusions there have close relations between TNF-α,IFN-γ,IL-8 and CHD.
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