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Glatiramer acetate(GA)是一种人工新合成的肽类制剂,由4种氨基酸组成。实验研究表明它对多发性硬化(multiple sclerosis,MS)及其动物模型即实验性自身免疫性脑脊髓炎(experimental autoimmune encephalo-myelitis,EAE)均有防治作用。试验表明,GA可成为治疗MS尤其是复发-缓解型MS(relapsing-remitting MS,RRMS)的一线药。人们对其作用机制也开始逐步认识。此文就GA治疗MS的作用机制作一综述。
Glatiramer acetate (GA) is a synthetic, artificial peptide that consists of four amino acids. Experimental studies have shown that it has a preventive and therapeutic effect on multiple sclerosis (MS) and its animal model of experimental autoimmune encephalo-myelitis (EAE). Experiments have shown that GA can be a first-line drug for the treatment of MS, especially relapsing-remitting MS (RRMS). People have begun to understand their mechanism of action. This article reviews the mechanism of action of GA on MS.