研究表明,前列腺素合成限速酶环氧合酶-2(cyclooxygenase-2,COX-2),在肿瘤的发生发展中有重要作用,其可刺激上皮细胞增生,抑制肿瘤细胞凋亡,促进肿瘤血管生成,增强肿瘤细胞侵袭力,介导机体免疫抑制和突变,而其中血管生成与恶性肿瘤生长、侵袭和转移有密切关系,是目前国内外恶性肿瘤生物学及治疗学领域研究的热点和难点。笔者就近两年来对环氧合酶-2在恶性肿瘤血管生成中作用机制的新研究进展和其抑制剂的临床应用的国外研究状况作一介绍。 Studies have shown that prostaglandin synthesis rate-limiting enzyme cyclooxygenase-2 (COX-2), in the occurrence and development of tumors has an important role, which can stimulate epithelial cell proliferation, inhibit tumor cell apoptosis and promote tumor Angiogenesis, enhance the invasiveness of tumor cells, mediate the immune suppression and mutation, and angiogenesis is closely related to the growth, invasion and metastasis of malignant tumor, which is the hot and difficult point in the field of malignant tumor biology and therapeutics at home and abroad . The author of the recent two years on cyclooxygenase-2 in malignant tumor angiogenesis mechanism of new research progress and its clinical application of inhibitors of foreign research status to make an introduction.