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目的:评价液基细胞学检测(TCT)联合人乳头瘤病毒(HPV)检测在宫颈病变筛查中的应用价值。方法:选取女性患者240例,其中70例行TCT检测阳性、80例行HPV检测阳性、90例行TCT联合HPV检测阳性,3组均经阴道镜取活检,以组织学为金标准对其检测结果进行分析。结果:TCT诊断、HPV诊断及TCT联合HPV诊断与组织病理学诊断的符合率分别为82.86%、76.25%、95.56%。TCT联合HPV诊断与TCT组比较差异有统计学意义(P<0.01),与HPV组比较差异有统计学意义(P<0.01)。结论:TCT联合HPV检测在筛查宫颈病变中比单纯TCT或者HPV检测更准确,符合率更高。
Objective: To evaluate the value of TCT combined with human papillomavirus (HPV) in the screening of cervical lesions. Methods: Totally 240 female patients were selected. Among them, 70 cases were positive for TCT test, 80 cases were positive for HPV test, 90 cases were positive for TCT combined with HPV test, and colposcopy was used for biopsy in all three groups. Histological examination was the gold standard Results were analyzed. Results The coincidence rates of TCT diagnosis, HPV diagnosis and TCT combined with HPV diagnosis and histopathological diagnosis were 82.86%, 76.25% and 95.56% respectively. The difference between TCT combined with HPV and TCT was statistically significant (P <0.01), and there was significant difference between HPV and TCT (P <0.01). Conclusion: TCT combined with HPV test in the screening of cervical lesions than TCT or HPV testing more accurate, with a higher coincidence rate.