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设计并合成了含有香豆素基团的自引发单体,与2-(2-甲氧基乙氧基)乙基甲基丙烯酸酯(MEO2MA)进行自缩合乙烯基共聚合后得到超支化聚合物H-PMEO2MA.以其作为大分子引发剂,进行二甲氨基乙基甲基丙烯酸酯(DMAEMA)的原子转移自由基聚合,合成了具有温度响应性的超支化星形聚合物H-PMEO2MA-star-PDMAEMA.将此超支化星形聚合物在水中自组装成胶束后,利用支化点处香豆素基团的光二聚性能,在λ=320 nm的紫外光照射下进行香豆素间的光交联反应,形成核交联胶束.此核交联胶束在254 nm紫外光照射下则会发生解交联反应.采用尼罗红作为模型药物,将其装载到超支化星形聚合物胶束中,研究了不同条件下的药物释放行为.
The self-initiated monomer containing coumarin groups was designed and synthesized to obtain hyperbranched polymer after self-condensation with 2- (2-methoxyethoxy) ethylmethacrylate (MEO2MA) H-PMEO2MA was synthesized by atom transfer radical polymerization of dimethylaminoethylmethacrylate (DMAEMA) as a macroinitiator to synthesize a H-PMEO2MA- star-PDMAEMA. After the hyperbranched star polymer was self-assembled into micelles in water, the coumarin group was irradiated at the wavelength of 320 nm by the photodimerizability of the coumarin group at the branching point Between the cross-linking reaction, the formation of nuclear cross-linked micelles.The nuclear cross-linked micelles under 254nm UV light will cross-linking reaction occurs using Nile red as a model drug, which is loaded into the hyperbranched star Shaped polymer micelles, the drug release behavior under different conditions was studied.