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目的:临床观察自拟肺愈宁方治疗中晚期肺癌的临床疗效。方法:将56例经细胞学、病理学确诊的原发性支气管肺癌患者采用简单随机对照方法分为联合治疗组(简称治疗组,28例)与化疗组(简称观察组,28例)。治疗组采用自拟肺愈宁方配合化疗治疗,观察组单纯采用化疗进行治疗。观察两组病灶、主症变化、Karnofsky评分、化疗不良反应以及肿瘤标志物(CEA、CA125)的变化。结果:临床观察显示,在部分主症(如胸痛、气急)和PLT降低方面,两组比较差异无显著性(P>0.05);在病灶、主症变化、Karnofsky评分,以及肿瘤标志物水平改善方面,治疗组均优于观察组,两组比较差异有统计学意义(P<0.05或P<0.01)。结论:自拟肺愈宁方能抑制肿瘤生长,具有稳定病灶、增效减毒及提高生存质量的作用,是治疗肺癌的有效方剂。
Objective: To observe the curative effect of self-made Feiyuning prescription on advanced lung cancer. Methods: Fifty-six patients with primary bronchogenic carcinoma confirmed by cytology and pathology were divided into the treatment group (n = 28) and the chemotherapy group (n = 28) by simple randomized controlled trial. The treatment group with self-made lung Yu Ning side with chemotherapy, the observation group was treated with chemotherapy alone. The changes of lesion, main symptom, Karnofsky score, adverse reactions of chemotherapy and tumor markers (CEA, CA125) were observed. Results: The clinical observation showed that there was no significant difference between the two groups (P> 0.05) in some of the main symptoms (such as chest pain, shortness of breath) and PLT decreased; in the lesions, the main symptoms, Karnofsky score and the level of tumor markers improved The treatment group were better than the observation group, the difference between the two groups was statistically significant (P <0.05 or P <0.01). CONCLUSION: Self-made Feiyuning can inhibit the growth of the tumor, has the function of stabilizing the lesion, increasing the efficiency and reducing the toxic and improving the quality of life, and is an effective prescription for the treatment of lung cancer.