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目的:探讨霉菌性食管炎患者的临床特点及发病因素。方法:对35例经胃镜及真菌学检查确诊为霉菌性食管炎患者的临床资料进行分析。结果:霉菌性食管炎可表现为反酸、吞咽疼痛、胸骨后疼痛不适或烧灼感等;合并浅表性胃炎15例、反流性食管炎9例、消化性溃疡8例、糖尿病6例、肾功能不全2例、结缔组织病2例等。结论:霉菌性食管炎发病可能与长期应用抗生素、高血糖、食管粘膜屏障破坏、食管动力障碍、免疫功能低下等多种因素相关。
Objective: To investigate the clinical features and pathogenesis of patients with fungal esophagitis. Methods: The clinical data of 35 patients diagnosed as fungal esophagitis by gastroscopy and mycological examination were analyzed. Results: Fungal esophagitis can be manifested as acid reflux, sore throat, post-sternal pain discomfort or burning sensation; combined superficial gastritis in 15 cases, reflux esophagitis in 9 cases, peptic ulcer in 8 cases, diabetes in 6 cases, 2 cases of renal insufficiency, connective tissue disease in 2 cases. Conclusion: The incidence of fungal esophagitis may be related to the long-term use of antibiotics, hyperglycemia, esophageal mucosal barrier destruction, esophageal motility disorders and immunocompromise.