胃蛋白酶是胃液中最重要的蛋白分解酶,消化性溃疡的发生与其对上消化道粘膜的侵袭作用有关。胃蛋白酶由多种同工酶组成,其中同工酶1可能是致溃疡性胃蛋白酶。胃蛋白酶原是其前身,可分为Ⅰ、Ⅱ两种类型,均可在血清中检测到。测定血清胃蛋白酶原Ⅰ、Ⅱ以及两者的比率,对判断胃十二指肠疾患有一定价值。 Pepsin is the most important proteolytic enzyme in gastric juice. The occurrence of peptic ulcer is related to the invasion of upper gastrointestinal mucosa. Pepsin consists of a variety of isozymes, of which isoenzyme 1 may be caused by ulcer pepsin. Pepsinogen is its predecessor, can be divided into Ⅰ, Ⅱ two types, can be detected in serum. Determination of serum pepsinogen Ⅰ, Ⅱ and the ratio between the two, to determine the risk of gastroduodenal disease have some value.