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目的:研究中国不同性别血浆脂蛋白(a)[Lp(a)]浓度与冠状动脉粥样硬化程度的关系。方法:将男女患者分别按冠状动脉狭窄程度分组,并计算冠状动脉病变积分,比较各组Lp(a)的差异及与冠状动脉积分的相关性。结果:无论男性还是女性,4组不同病变的Lp(a)浓度分布差异有统计学意义,P<0.01;仅多支病变组与0支病变组比较差异有统计学意义,女性P<0.01,男性P<0.05。绝经后女性Lp(a)水平高于绝经前,P<0.05。结论:在中国,Lp(a)水平与冠状动脉粥样硬化的严重程度成正相关关系,且女性和男性都存在。女性绝经后血浆Lp(a)浓度升高,血浆Lp(a)浓度受性激素的调节。
Objective: To study the relationship between plasma lipoprotein (a) [Lp (a)] levels and coronary atherosclerosis in China. Methods: The male and female patients were grouped according to the degree of coronary artery stenosis, and the coronary artery disease scores were calculated. The differences of Lp (a) and coronary artery score were compared between the two groups. Results: There was significant difference in the distribution of Lp (a) among 4 groups of different pathological changes, both male and female, P <0.01. There was significant difference between the multi-vessel lesion group and 0-vessel lesion group only (P <0.01) Male P <0.05. The level of Lp (a) in postmenopausal women was higher than that in premenopausal women (P <0.05). Conclusions: In China, Lp (a) levels have a positive correlation with the severity of coronary atherosclerosis, both in women and men. After menopause, plasma Lp (a) concentration is elevated and plasma Lp (a) concentration is regulated by sex hormones.