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目的:探讨益气养阴活血方防治经皮冠状动脉介入治疗后再狭窄的可能性。方法:将健康新西兰兔30只随机分为正常组、模型组、西药对照组和中药治疗组。通过喂养高脂饲料同时予以腹主动脉内膜剥脱术的方法造成兔动脉内膜损伤,术后2周取材,RT-PCR法测定c-myc和PDGF-BB水平。结果:正常组和中药治疗组PDGF-BB和c-myc水平明显低于模型组(P<0.01,P<0.05),西药对照组PDGF-BB水平比模型组显著降低(P<0.05);c-myc和PDGF-BB mRNA呈正相关,模型组相关系数为8.603,P<0.05,中药治疗组相关系数为2.672,P<0.05。结论:中药通过抑制c-myc的表达来抑制PDGF-BB的合成和分泌。提示益气养阴活血方可能具有防治经皮冠状动脉介入治疗后再狭窄的作用。
Objective: To explore the possibility of Yiqi Yangyin Huoxue Decoction in preventing restenosis after percutaneous coronary intervention. Methods: Thirty healthy New Zealand rabbits were randomly divided into normal group, model group, western medicine control group and traditional Chinese medicine treatment group. Intimal injury was induced in rabbits by feeding high-fat diet with abdominal aortic intima stripping. Rabbits were harvested 2 weeks after operation and the levels of c-myc and PDGF-BB were determined by RT-PCR. Results: The levels of PDGF-BB and c-myc in the normal group and the traditional Chinese medicine treatment group were significantly lower than those in the model group (P<0.01, P<0.05). The level of PDGF-BB in the western medicine control group was significantly lower than that in the model group (P<0.05); There was a positive correlation between -myc and PDGF-BB mRNA. The correlation coefficient of the model group was 8.603, P<0.05. The correlation coefficient of the Chinese medicine treatment group was 2.672, P<0.05. Conclusion: Traditional Chinese medicine inhibits the synthesis and secretion of PDGF-BB by inhibiting the expression of c-myc. Tip Yiqi Yangyin Huoxue Fang may have the effect of preventing restenosis after percutaneous coronary intervention.