近年研究发现 ,细胞周期调控机制紊乱是细胞增生失控从而导致癌变的重要原因。哺乳动物中 ,一个典型的细胞周期由有严格顺序并循精确时相的 4个期即 G1 - S- G2 - M构成 ,并受到胞内外信号传导途径及反馈环路的调控 [1 ] 。其中 ,G1期是细胞增生周期的关键。目前已发现A- J10种 In recent years, studies have found that the disorder of the cell cycle regulation mechanism is an important reason for the uncontrolled cell proliferation resulting in cancer. In mammals, a typical cell cycle consists of four phases, G1 - S-G2-M, which are strictly sequenced and precisely followed, and are regulated by the intracellular and extracellular signaling pathways and feedback loops [1]. Among them, G1 phase is the key cell cycle. A-J10 has been found