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根据临床研究报告,用异菸肼治疗粟粒性肺结核及渗出性肺结核,其卓越之疗效,已无异言。链霉素对於各种结核性疾病,尤其特殊性的结核和骨结核、脑膜结核亦有一定之疗效。然而对慢性肺结核其治疗效果尚成问题,若病灶已有空洞形成,则其疗效更为不佳,究其原因: 1.据Ceatti氏报告结核性空洞形成或乾酪化的病灶,四周血管分布稀少,大部份血管已有?血栓形成,故链霉素经肌肉注射後不易充分达到分散在结核病灶内,曾作试验证明,链霉素注射後散布在血管、支气管及肋膜内的浓度皆较结核空洞为高。 2.因其药物药理性质不同,链霉素系尿碱
According to clinical research reports, with isoniazid treatment of miliary tuberculosis and exudative pulmonary tuberculosis, its excellent curative effect, there is no difference. Streptomycin for a variety of tuberculosis disease, especially the special tuberculosis and bone tuberculosis, meningeal tuberculosis also have a certain effect. However, its therapeutic effect on chronic pulmonary tuberculosis is still a problem, if the lesion has been the formation of voids, the curative effect is even more poor, the reason: 1. According to Ceatti’s report of tuberculous voids or cheese-forming lesions, peripheral vascular thinly distributed , Most of the blood vessels have been thrombosis, it is not easy to reach streptomycin streptomycin after intramuscular injection of scattered in the tuberculosis lesions, experiments have shown that streptomycin injection spread in the blood vessels, bronchial and pleural concentrations were Tuberculous cavity is high. 2. Because of its pharmacological properties of different, streptomycin-based urine