论文部分内容阅读
作者以正常的或荷瘤的(荷实体型ERLICH乳腺癌)ICR系小鼠的腹腔巨噬细胞(简称Mφ)和脾脏组织为材料,观察了β-胡萝卜素对小鼠Mφ功能和自然杀伤(NK)细胞活性的影响。结果表明:β-胡萝卜素(15mg/kg,po d_(1-15)),对正常小鼠Mφ功能和NK细胞活性影响不明显(P>0.05)。但给予β-胡萝卜素(15mg/kg po d_(1-22)),能提高荷瘤小鼠Mφ的吞噬功能(P<0.05)和NK细胞活性(P<0.01),并能对抗环磷酰胺的免疫抑制作用,与单用环磷酰胺的小鼠比较,有显著的差异(P<0.05)。
The authors used normal or tumor-bearing (solid-state ERLICH breast cancer) ICR mice’s peritoneal macrophages (abbreviated Mφ) and spleen tissue as materials to observe the function and natural killing of mouse Mφ by β-carotene. The effect of NK) cell activity. The results showed that β-carotene (15 mg/kg, po d_(1-15)) had no significant effect on Mφ function and NK cell activity in normal mice (P>0.05). However, administration of β-carotene (15 mg/kg po d_(1-22)) increased the phagocytic function (P<0.05) and NK cell activity of tumor-bearing mice Mφ (P<0.01) and was able to counteract cyclophosphamide. The immunosuppressive effect was significantly different from that of cyclophosphamide alone (P<0.05).