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目的:从发病机制和病理组织学角度探讨单纯性无排卵性子宫内膜与子宫内膜简单型增生的诊断标准与鉴别诊断,明确二者的界限和病理诊断工作中的误区,为临床治疗提供准确参考,防止误诊和过度治疗。方法:应用免疫组织化学法检测雌激素受体(ER)、孕激素受体(PR)和Ki-67 3种标记物在各组子宫内膜中的表达,在形态学的基础上进一步探讨两种子宫内膜病变的诊断和鉴别诊断。结果:各组子宫内膜ER表达差异无统计学意义(P>0.05);PR在单纯性无排卵性子宫内膜中表达较高(P<0.05);Ki-67在子宫内膜简单型增生中表达较高(P<0.05)。结论:无论在病理组织学上还是在PR与Ki-67的表达上两组病变比较差异均有统计学意义。病理诊断医生应当也能够将两者区分开来,以利于临床治疗工作正确合理地进行。
Objective: To explore the diagnostic criteria and differential diagnosis of simple anovulatory endometrium and endometrial simple hyperplasia from the pathogenesis and histopathological point of view, to clarify the boundaries between the two and the errors in the pathological diagnosis work for the clinical treatment Accurate reference to prevent misdiagnosis and over-treatment. Methods: The expression of estrogen receptor (ER), progesterone receptor (PR) and Ki-67 in the endometrium was detected by immunohistochemistry. Based on the morphology, the expression of two Endometrial lesions of the diagnosis and differential diagnosis. Results: There was no significant difference in the expression of ER in each group (P> 0.05). The expression of PR was higher in simple anovulatory endometrium (P <0.05), while the expression of Ki-67 in simple endometrial hyperplasia (P <0.05). Conclusion: There is significant difference between the two groups in the pathological histology and the expression of PR and Ki-67. Pathological diagnosis of doctors should also be able to distinguish between the two in order to facilitate the correct and reasonable clinical treatment.