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典型的细菌性痢疾,在临床上不难诊断.由于抗生素药物的长期使用,细菌常发生变异,出现很多非典型菌株,给细菌学诊断及治疗带来了一定困难,现就非典型菌痢的细菌学诊断谈点体会.在实际工作中,常发现一些非典型菌株,大致可分两类:一类是生化反应符合志贺氏菌属,而与已知所有志贺氏菌属诊断血清不发生凝集;另一类是生化反应不符合,但与志贺氏菌多价血清或某一单价血清发生不同程度的凝集.对这两类型的非典型菌株,首先应对其特性的稳定性进行观察,通常采用传代法让其还祖.即用胆盐琼脂或普通琼脂反复传代(一般十代左右);亦可用小白鼠接种传
Typical bacillary dysentery is clinically not difficult to diagnose.Because of the long-term use of antibiotics, bacteria often mutate and there are many atypical strains, which have brought certain difficulties to bacteriological diagnosis and treatment. Bacteriological diagnosis point to talk about experience.In practice, often found in some atypical strains, can be divided into two categories: one is biochemical reactions consistent with Shigella, and with all known Shigella is no diagnostic serum The other is biochemical reaction does not conform to, but with Shigella multivalent serum or a monovalent serum agglutination to varying degrees.For these two types of atypical strains, we should first observe the stability of its characteristics , Usually pass the law so that its ancestors. That is, bile salt agar or ordinary passage of repeated passage (usually about ten generations); can also be used mice inoculation