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1975年以来,我研究室发现一些双苄基异喹啉类生物硷对大白鼠实验性矽肺具有明显疗效,为矽肺治疗药物的研究提供了新的思路。为了进一步探讨这类化合物化学结构与生物活性之间的关系,为寻找高效低毒的矽肺治疗药物提供依据。我们制备了一些不同结构的双苄基异喹啉类生物硷(以下简称BIQ),比较了它们对大鼠实验性矽肺的疗效和对血浆蛋白的作用,对这类化合物的构效关系进行了初步探讨。
Since 1975, my lab has found that some dibenzyl isoquinoline alkaloids have significant therapeutic effects on experimental silicosis in rats, which provides a new idea for the study of silicosis drugs. In order to further explore the chemical structure of these compounds and the relationship between biological activity in order to find efficient and low toxicity of silicosis drugs provide the basis. We prepared a number of different structures of bis-benzyl isoquinoline alkaloids (hereinafter referred to as BIQ), compared their efficacy in experimental silicosis and the role of plasma proteins, the structure-activity relationship of these compounds were Preliminary discussion.