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低氧诱导因子-1(HIF-1)是一种核转录因子,存在于多种肿瘤细胞中,通过激活下游的多种靶基因调节氧平衡,使肿瘤耐受缺氧环境,促进肿瘤进展。其在乳腺癌中表达,与乳腺癌的增殖、侵润转移关系密切。
Hypoxia-inducible factor-1 (HIF-1) is a nuclear transcription factor that exists in many tumor cells and regulates the oxygen balance by activating downstream target genes to make the tumor tolerant to hypoxic environment and promote tumor progression. Its expression in breast cancer, and breast cancer proliferation, invasion and metastasis are closely related.