本文报道急性心肌梗塞(AMI)发病4h 内静注噻吗心安(timolol,β-受体阻滞剂)和安慰剂的随机双盲多中心对照研究结果。研究对象为65例首次 AMI 发病4h 内入院的患者,不论男女均剔除心动过缓(<50/min),低血压(收缩压<100mmHg)、罗音超过膈上10cm、通气障碍和任何程度的房室传导阻滞、QRS 间期>0.11sec,以及正使用其它强心剂、解热药者。首剂噻吗心安剂量1mg 或以等量盐水静注,随 This article reports the results of a randomized double-blind, multicenter study of intravenous timolol (β-blocker) and placebo within 4 hours of onset of acute myocardial infarction (AMI). The study population consisted of 65 patients admitted within 4 hours after the first AMI onset. Both men and women excluded bradycardia (<50 / min), hypotension (systolic blood pressure <100 mmHg), rales over the diaphragm, ventilation difficulties and any degree of Atrioventricular block, QRS interval> 0.11sec, and other cardiac drugs are being used to relieve fever. The first dose of timolol 1mg intravenous or intravenous injection, with