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有资料显示不动杆菌在院内感染中的发生率正在增加 ,由此导致的死亡率也很高。本研究对我院 1998年 9月至 1999年 7月间 735份痰菌阳性标本进行分离培养 ,其中不动杆菌 87例 ,发生率为 11.84% ,较过去的 8.2 1%有所升高 (P<0 .0 5 )。本文用 11种抗菌药物对不动杆菌的敏感性测定结果表明 ,硫酸依替米星敏感率为 88.5 7% ,低于头孢哌酮 /舒己坦 (93.94% )位于第二位。 10例主要为 COPD、支气管扩张肺炎住院病人接受硫酸依替米星治疗 ,0 .2 g加入 10 0 ml生理盐水中静脉滴注 ,qd,5～ 7d为一疗程 ,疗效按国家统一判定标准评价 ,治愈 5例 ,好转 3例 ,进步 1例 ,无效 1例 ,有效率为 80 %。细菌清除率为 70 % ,替换 10 % ,未清除2 0 %。认为硫酸依替米星在不动杆菌感染治疗方面是有效、安全、方便、经济的选择。
Data show that the incidence of Acinetobacter in nosocomial infections is increasing, the resulting mortality is also high. In this study, 735 sputum positive specimens were isolated and cultured in our hospital from September 1998 to July 1999, including 87 cases of Acinetobacter, the incidence rate was 11.84%, which was higher than the 8.21% in the past (P <0 .0 5). In this paper, the sensitivity of 11 kinds of antibacterials to Acinetobacter was determined. The sensitivity of etimicin was 88.5%, lower than that of cefoperazone / shugatan (93.94%). 10 patients were mainly COPD, bronchial pneumonia inpatients treated with etimicin sulfate, 0.2 g added to 10 ml of normal saline intravenously, qd, 5 ~ 7d for a course of treatment according to the national uniform evaluation criteria , 5 cases were cured, 3 cases improved, 1 case improved, 1 case ineffective, and the effective rate was 80%. Bacterial clearance was 70%, 10% replaced and 20% not cleared. It is considered that etimicin sulfate is an effective, safe, convenient and economical choice for the treatment of Acinetobacter infections.