目的：探讨卡铂在不同途径盆腔动脉灌注化疗组织血浆中药物浓度的分布规律。方法：选择实验用雌犬１３只，随机分为双髂内动脉灌注组（Ａ组）及腹壁下动脉插管灌注组（Ｂ组），以卡铂（１２ｍｇ／ｋｇ）灌注化疗后在不同的时间点分别取子宫、卵巢组织及静脉血，用原子吸收光谱法测定上述３种组织内的铂离子浓度。结果：①Ａ组子宫组织铂浓度的峰值：（１９１３４±７０６０）ｎｇ／ｇ，ＡＵＣ（药时曲线下面积）０～２４０ｍｉｎ：（６３６６±６４１）ｎｇ／（ｇ·ｍｉｎ）。明显高于Ｂ组峰值（１４８９１±１１５２）ｎｇ／ｇ，ＡＵＣ０～２４０ｍｉｎ：（３５２６±６５０）ｎｇ／（ｇ·ｍｉｎ）。②两组卵巢组织铂离子浓度明显低于相对应的子宫组织，峰值分别为（１９３６±５５９）ｎｇ／ｇ、（２２１９±２９９）ｎｇ／ｇ，但ＡＵＣ０～２４０ｍｉｎＡ组（４３９３±８９０）ｎｇ／（ｇ·ｍｉｎ）明显高于Ｂ组（３３１４±３５１）ｎｇ／（ｇ·ｍｉｎ），Ｐ＜００１；③两组血浆中峰值及ＡＵＣ０～２４０ｍｉｎ均较低，差别无意义；④Ａ组子宫组织铂浓度明显高于卵巢（见上），但Ｂ组中仅峰值差别有意义而ＡＵＣ０～２４０ｍｉｎ差别不大。结论：双髂内动脉灌注化疗明显优于? OBJECTIVE: To investigate the distribution of drug concentration of plasma carboplatin in different ways of pelvic arterial infusion chemotherapy. Methods: Thirteen experimental female dogs were randomly divided into two internal iliac arterial perfusion group (A group) and inferior epigastric artery cannulation perfusion group (group B) after infusion of carboplatin (12mg/kg) after chemotherapy. Uterus, ovarian tissue and venous blood were taken at different time points, and platinum ion concentrations in the above three tissues were determined by atomic absorption spectrometry. RESULTS: The peak value of platinum concentration in uterine tissue in group 1A was (19134±7060) ng/g, and AUC (area under the curve) was 0-240min: (6366±641) ng/(g·min). Significantly higher than the peak value of group B (148  91 ± 11  52) ng/g, AUC 0 240 240 min: (3526 650 650) ng/(g min min). 2 The platinum ion concentration in the ovarian tissues of the two groups was significantly lower than that of the corresponding uterine tissue, with peak values ​​of (1936±559) ng/g, (2219±299) ng/g, but AUC0~240minA. The group (4393±890) ng/(g·min) was significantly higher than that of the group B (3314±351) ng/(g·min), P<001; 3 The plasma peak and AUC 0~240 min were lower in both groups. The difference was not significant; the platinum concentration in the uterine tissue in the 4A group was significantly higher than that in the ovary (see above), but only the peak difference in the B group was significant while the difference in the AUC0-240 min was not significant. Conclusion: Bi-internal arterial infusion chemotherapy is significantly better than