目的探讨国产消旋聚乳酸（ＰＤＬＬＡ）接骨板在动物体内的降解过程和影响因素。方法运用国产ＰＤＬＬＡ接骨板行犬下颌骨体部人工骨折内固定，并在股部埋植ＰＤＬＬＡ接骨板作为对照。观察不同时期下颌骨体部骨折区和股部埋植区国产ＰＤＬＬＡ接骨板大体降解情况、骨折愈合情况以及完整的接骨板表面扫描电镜观察结果的变化情况。结果植入前国产ＰＤＬＬＡ接骨板表面光滑，消旋聚乳酸分子间结合紧密；随着时间的推移，植入的ＰＤＬＬＡ接骨板表面降解痕迹逐渐明显，消旋聚乳酸分子间的降解孔隙和密度逐步增大，而且骨折区ＰＤＬＬＡ接骨板的降解速度比股部埋植区更快；骨折愈合情况良好。结论国产ＰＤＬＬＡ接骨板能够在体内逐步自行降解吸收；其降解过程与骨折的愈合过程相吻合，并能够促使骨折早期愈合 Objective To investigate the degradation process and influencing factors of domestic PDLLA plate in animal. Methods The domestic PDLLA plate was implanted into the canine mandibular body with artificial fracture, and PDLLA plate was implanted in the femoral area as a control. To observe the general degradation of PDLLA plate, the healing of fractures and the changes of the complete surface of bone plate by scanning electron microscopy in different periods of mandibular body and femoral implants. Results The surface of domestic PDLLA plate was smooth and the polylactide molecules were tightly bound before implanted. With the passage of time, the surface degradation of PDLLA plate implanted gradually became obvious. The degraded pores and densities between PDLLA molecules gradually increased Increased, and PDLLA plate fracture area degradation rate faster than the implants; fracture healing is good. CONCLUSION: PDLLA plate can be gradually degraded and absorbed in vivo. The degradation process is consistent with the healing process of fractures and can promote early fracture healing