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人类胎儿血红蛋白γ链有二种类型:一种在136位上是甘氨酸(Gly),另一种是丙氨酸(Ala),分别称为Gγ链和Aγ链。它们是由非等位基因Gγ和Aγ分别控制的。此外,正常人的γ链在75位上的氨基酸是异亮氨酰残基,近年来发现有些γ链的第75位的氨基酸被苏氨酸(Thr)残基所代替,称为γ链。本文就Tr链的发生频率及遗传学的研究结果进行了分析和讨论。作者从脐血检查获得的资料表明Tγ链的频率与种族来源和地理位置有关。对不同人种和地方来源的脐带194例中检出朽例Tγ链,Tγ链发生频率是0.12,新生儿Tγ杂合子平均有17-19％的Tγ链,而纯合子Tγ链平均值达31％。在检查的5例镰形细胞
There are two types of human fetal hemoglobin gamma chain: one is glycine (Gly) at position 136 and the other is alanine (Ala), known as the Gγ chain and the Aγ chain, respectively. They are controlled by the non-allelic Gγ and Aγ, respectively. In addition, the amino acid at position 75 of the normal human γ chain is an isoleucyl residue. In recent years, it has been found that the 75th amino acid of some γ chain is replaced by a threonine (Thr) residue and is called a γ chain. In this paper, the frequency and genetics of Tr chain were analyzed and discussed. The data obtained by the authors from cord blood tests indicate that the frequency of Tγ chains is related to ethnic origin and geographical location. In 194 cases of umbilical cord from different ethnic and local sources, the decayed Tγ chain was detected, the frequency of Tγ chain was 0.12, and the average of Tγ heterozygotes of neonates was 17-19% %. Five sickle cells were examined