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已经证明致病微生物的蛋白酪氨酸磷酸酯酶(PTPase)能够破坏宿主细胞肌动蛋白的细胞骨架。为了探索溶组织内阿米巴的分泌性酸性磷酸酶(SAP)是否具有磷酸酪氨酸磷酸酯酶的活性以及这种活性参与破坏宿主细胞的潜力 ,研究者首先测定了能够在酸性环境中水解对硝基磷酸盐 (p NPP)的SA
The protein tyrosine phosphatase (PTPase) of pathogenic microorganisms has been shown to disrupt the cytoskeleton of host cell actin. To explore whether E. coliolytica secreted acid phosphatase (SAP) possesses phosphotyrosine phosphatase activity and the potential for this activity to participate in disrupting host cells, the investigators first determined the ability to hydrolyze Paranitrophosphate (p NPP) of SA