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目的 :探讨脑脊液细胞学检查结合免疫组化染色对脑膜癌病 (MeningealCarcinomatosis,MC)的诊断价值。方法 :脑脊液细胞学检查用侯氏自然沉淀法和粟氏玻片离心法 ,免疫组化染色用SP法。结果 :1 5例经脑脊液细胞学检查均发现异常细胞。结合免疫组化染色 1 0例 ,其中 5例用常规涂片 ,异常细胞阳性率 2 0 % ,5例用脑脊液细胞学收集细胞法异常细胞阳性率 80 % ,5例中 1例血清癌胚抗原 (CEA)阳性 ,1例细胞角蛋白 (CK)阳性 ,2例CEA、CK均阳性。结论 :脑脊液细胞学检查结合细胞免疫组化染色是诊断脑膜癌病的重要手段
Objective: To investigate the diagnostic value of cerebrospinal fluid cytology and immunohistochemistry in the diagnosis of Meningeal Carcinomatosis (MC). Methods: Cytological examination of cerebrospinal fluid with Hou’s natural precipitation method and Suans glass slide centrifugation, immunohistochemical staining using SP method. Results: Abnormal cells were found in all 15 cases of cerebrospinal fluid cytology. In combination with immunohistochemical staining, 10 cases were found by immunohistochemical staining, of which 5 cases were smear-positive, the positive rate of abnormal cells was 20%, the positive rate of abnormal cells by cytopathology was 5% in 5 cases and 80% (CEA) positive, 1 case of cytokeratin (CK) positive, 2 cases of CEA, CK were positive. Conclusion: CSF cytology combined with immunohistochemical staining is an important means of diagnosis of meningeal carcinomatosis