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氨苯砜(DDS)耐药菌株的广泛发生是目前治疗上的重大问题。为了不致使这问题变得更为严重,目前普遍认为,所有新瘤型病人治疗的开始阶段均应联合应用抗麻风药物。较理想的方案是足量DDS(每天50～100毫克)加利福平或B_(663)。但由于利福平价昂和B_(663)使皮肤变色,限制了这两个药物的使用。因此寻找其他药物供作交替使用显得十分必要。本文是报告氨硫脲、丁氨苯硫脲、异戊羟苯硫脲(Thiocarlide)和磺胺甲氧嗪的最低有效剂量(MED)、最低抑菌浓度(MIC)及其杀菌活性。材料与方法:6株麻风杆菌均取自未经治疗的瘤型病人。测定MED采用Rees(1965)介绍的方法,接种菌量104,用连续法。喂食浓度从0.001%至0.2%不等。杀菌活性的估计按照Shepard(1967)
The widespread occurrence of dapsone (DDS) -resistant strains is currently a major medical problem. In order not to exacerbate the problem, it is now generally agreed that anti-leprosy drugs should be used in combination with the initial phase of treatment for all new neoplastic patients. A more desirable regimen is adequate DDS (50 to 100 mg daily) of either risperidone or B_ (663). However, the use of these two drugs has been limited by the fact that rifampicin is expensive and B_ (663) discolors the skin. So looking for other drugs for alternate use is necessary. This article reports the minimum effective dose (MED), minimum inhibitory concentration (MIC) and their bactericidal activity for the thiosemicarbazones, butaniline, thiocholide and sulfamethoxazine. MATERIALS AND METHODS: Six strains of leprosy were collected from untreated tumor patients. Determination of MED using the method described by Rees (1965), inoculation bacteria 104, with a continuous method. Feeding concentrations ranged from 0.001% to 0.2%. The bactericidal activity was estimated according to Shepard (1967)