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目的研究门静脉血Ｋ一ｒａｓ、ｐ５３基因与大肠癌肝转移的关系。方法对３０例大肠癌患者的癌组织、门静脉血、外周静脉血分别检测相关基因突变，随访手术后２年内肝转移率并作统计学分析。结果门静脉血Ｋ－ｒａｓ、ｐ５３基因突变阳性率分别为２０％与３３．３％，与Ｄｕｋｅｓ分期有显著关系，与术后异时相肝转移有显著关系。结论检测门静脉血Ｋ一ｒａｓ、ｐ５３基因突变对大肠癌患者预后判断有帮助．对早期发现肝微小转移灶有意义。
Objective To study the relationship between K-ras and p53 gene in portal vein and hepatic metastasis of colorectal cancer. Methods 30 cases of colorectal cancer patients with cancer, portal vein blood and peripheral venous blood were detected gene mutations were followed up for 2 years after liver metastasis rate and for statistical analysis. Results The positive rates of K-ras and p53 gene mutations in portal vein were 20% and 33.3%, respectively. The positive rates of K-ras and p53 gene in portal vein were significantly correlated with Dukes stage and significant correlation with heterotopic liver metastasis. Conclusion Detection of K-ras and p53 mutations in portal vein blood is helpful for the prognosis of patients with colorectal cancer. On the early detection of liver micrometastasis meaningful.