特发性血小板减少性紫癜(idiopathic thrombocy-topenic purpura,ITP)是一种获得性自身免疫性疾病,以自身抗体产生破坏血小板,导致血小板减少引起皮肤黏膜出血为临床特征的疾病。尽管ITP的临床特点很重要,但ITP的诊断仍为排除性诊断[1]。50年前,Harrington及其后续的研究证实了抗血小板膜自身抗体的存在,自身抗体加速血小板在脾脏的清除,不同的前瞻性研究也表明如检测到血小板自身抗体,对ITP的诊断有很重 Idiopathic thrombocytopenic purpura (idiopathic thrombocytopenic purpura, ITP) is an acquired autoimmune disease, autoantibodies produce damage to platelets, resulting in thrombocytopenia skin mucosal bleeding is a clinical feature of the disease. Although the clinical features of ITP are important, the diagnosis of ITP is still an exclusionary diagnosis [1]. Fifty years ago, Harrington and his follow-up studies confirmed the presence of anti-platelet membrane autoantibodies and autoantibodies to accelerate platelet clearance in the spleen. Different prospective studies have also shown that if platelet autoantibodies are detected, the diagnosis of ITP is severe